Advanced Biologics for Faster Healing—Anywhere, Anytime
Advanced wound grafts are bioengineered or naturally derived materials used to promote healing in chronic or complex wounds. They provide a scaffold for tissue regeneration, stimulate cellular activity, and can be applied easily in home or mobile settings.
1. Placental Allografts (Amnion/Chorion)
Derived from donated placental tissue, rich in growth factors and anti-inflammatory cytokines.
Ideal for: Chronic ulcers, post-surgical wounds, exposed tendon/bone
Products: carePATCH™, Restorigin™, completeFT™, ACA Patch™
Evidence: Up to 72% complete closure in 12 weeks (JWC, 2023)
2. Acellular Dermal Matrices (ADMs)
Human cadaveric skin processed to remove cells, leaving a collagen scaffold.
Ideal for: Deep wounds needing dermal regeneration
Products: Coll-E-Derm™, DermACELL®, Integra®
Evidence: Improved graft integration and vascularization (Wound Rep Reg, 2022)
3. Bioengineered Skin Substitutes
Lab-grown constructs with or without living cells, mimicking dermis and epidermis.
Ideal for: Venous ulcers, diabetic ulcers
Products: Apligraf®, Dermagraft®
Evidence: FDA-approved for DFUs/VLUs with higher healing rates vs. SOC
4. Porcine Xenografts
Derived from pig skin, offering temporary biologic cover and reducing bioburden.
Ideal for: Burns, trauma wounds, donor sites
Products: PriMatrix®, XenMatrix®
Evidence: Biocompatibility with human tissue; supports early wound closure
5. Collagen-Based Gras
Made from bovine or porcine collagen, often combined with silver or growth factors.
Ideal for: Partial-thickness wounds, low-exudate ulcers
Products: Promogran™, Puracol®, Biostep®
Evidence: Stimulates cellular migration and angiogenesis (Wounds, 2021)
Clinical Benefits Across Graft Types:
- ✔️Accelerated healing
- ✔️Reduced inflammation & infection
- ✔️Supports tissue regeneration
- ✔️Decreases number of visits
- ✔️Easy to store and apply in the field
Who Can Benefit?
- Diabetic Foot Ulcers (DFUs)
- Venous Leg Ulcers (VLUs)
- Pressure Injuries (Stages 3-4)
- Post-surgical & dehisced wounds
- Burns or trauma wounds
- Wounds with exposed structures
Reimbursement Essentials
- CPT: 15271–15278 (skin substitute application)
- HCPCS: Q4xxx, A2001–A2019 (product-specific codes)
- Modifiers: -59, -RT/-LT, -KX
- ICD-10: L97.xx, I83.xx, E11.621, etc.
Documentation Must Include:
- Chronicity and failure of conservative care
- Justification for biologic treatment
- Location, size, tissue exposure
- Product details (type, lot #, expiration)
Let’s advance healing—together, one wound at a time.